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AZD4635
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AZD4635图片
CAS NO:1321514-06-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
AZD4635 (HTL1071) 是一种有效的、选择性的和口服活性的腺苷 A2A 受体 (A2AR) 拮抗剂。 AZD4635 与人 A2AR 结合，Ki 为 1.7 nM，比其他腺苷受体选择性高 30 倍以上。
Cas No.1321514-06-0
别名HTL1071; AZD4635
Canonical SMILESNC1=NC(C2=CC=C(F)C=C2)=C(C3=CC(Cl)=NC(C)=C3)N=N1
分子式C15H11ClFN5
分子量315.73
溶解度DMSO : ≥ 83.3 mg/mL (263.83 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AZD4635 is a potent and selective, orally available adenosine A2A receptor (A2AR) antagonist. AZD4635 binds to human A2AR with a Ki of 1.7 nM and with >30-fold selectivity over other adenosine receptors[1].

In the presence of 0.1, 1 and 10 μM adenosine, the IC50s of AZD4635 for inhibition of cAMP production are 0.79, 10.0 and 142.9 nM, respectively[1].

References:
[1]. Alexandra Borodovsky, et al. Abstract 5580: Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5580.