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Daclatasvir-d6
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Daclatasvir-d6图片
CAS NO:1801709-41-0
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of daclatasvir
Cas No.1801709-41-0
别名BMS-790052-d6; EBP 883-d6
Canonical SMILESO=C([C@H](C(C)C)NC(OC([2H])([2H])[2H])=O)N1CCC[C@H]1C2=NC=C(C(C=C3)=CC=C3C4=CC=C(C5=CN=C([C@@H]6CCCN6C([C@@H](NC(OC([2H])([2H])[2H])=O)C(C)C)=O)N5)C=C4)N2
分子式C40H44D6N8O6
分子量744.9
溶解度DMSO: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Daclatasvir-d6 is intended for use as an internal standard for the quantification of daclatasvir by GC- or LC-MS. Daclatasvir is a first generation direct-acting inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A; Kds = 8 and 210 nM for the NS5A33-202 and NS5A26-202 residues of HCV genotype 1b, respectively).1,2 It potently inhibits HCV replication in multiple HCV replicon genotypes (EC50s = 9-146 pM) with the highest potency in genotypes 1b and 4a (EC50s = 9 and 12 pM, respectively).1 Daclatasvir disrupts the subcellular localization of NS5A in Huh7.5 cells and inhibits viral RNA synthesis and virion assembly and secretion when used at a concentration of 1 nM in HCV-infected Huh7 cells.3,4 Daclatasvir also inhibits organic anion transport polypeptides 1B1 (OAT1B1) and OAT1B3 (IC50s = 1.5 and 3.27 μM, respectively).5 Formulations containing daclatasvir have been used alone and in combination with NS3/4A and NS5B inhibitors in the treatment of HCV.

|1. Gao, M., Nettles, R.E., Belema, M., et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature 465(7294), 96-100 (2010).|2. Ascher, D.B., Wielens, J., Nero, T.L., et al. Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Sci. Rep. 4, 4765 (2014).|3. Lee, C., Ma, H., Hang, J.Q., et al. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. Virology 414(1), 10-18 (2011).|4. Guedj, J., Dahari, H., Rong, L., et al. Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life. Proc. Nat. Acad. Sci. USA 110(10), 3991-3996 (2013).|5. Furihata, T., Matsumoto, S., Fu, Z., et al. Different interaction profiles of direct-acting anti-hepatitis C virus agents with human organic anion transporting polypeptides. Antimicrob. Agents Chemother. 58(8), 4555-4565 (2014).