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C24(2'(R)-hydroxy)Phytoceramide(t18:0/24:0)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C24(2'(R)-hydroxy)Phytoceramide(t18:0/24:0)图片
CAS NO:154801-30-6
包装:1mg
市场价:741元

产品介绍
A bioactive sphingolipid
Cas No.154801-30-6
Canonical SMILESOC[C@H](NC([C@H](O)CCCCCCCCCCCCCCCCCCCCCC)=O)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O
分子式C42H85NO5
分子量684.1
溶解度Chloroform:Methanol (4:1): soluble,Ethanol: warmed
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

C24 (2'(R)-hydroxy) Phytoceramide is a naturally occurring sphingolipid that has been found in adlay seed hull.1 It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 19 μg/ml), as well as increases in COX-2 and inducible nitric oxide synthase (iNOS) levels. It increases production of chemokine (C-X-C motif) ligand 8 (CXCL8), CXCL1, chemokine (C-C motif) ligand 2 (CCL2), and CCL20 in human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner.2 C24 (2'(R)-hydroxy) Phytoceramide is a hydroxylated form of C24 phytoceramide . [Matreya, LLC. Catalog No. 2094]

|1. Huang, D.-W., Chung, C.-P., Kuo, Y.-H., et al. Identification of compounds in adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) seed hull extracts that inhibit lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. J. Agric. Food Chem. 57(22), 10651-10657 (2009).|2. Sekiya, M., Ueda, K., Okazaki, K., et al. A phytoceramide analog stimulates the production of chemokines through CREB activation in human endothelial cells. Int. Immunopharmacol. 11(10), 1497-1503 (2011).