4-Methylumbelliferyl 6-thio-Palmitate-β-D-Glucopyranoside 是棕榈酰蛋白硫酯酶 (PPT) 的荧光底物。
| Cas No. | 229644-17-1 |
| 别名 | 4-甲基-7-[[6-S-(1-氧代十六烷基)-6-硫代-BETA-D-吡喃葡萄糖基]氧基]-2H-1-苯并吡喃-2-酮 |
| Canonical SMILES | O=C1C=C(C)C2=C(C=C(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)C(CSC(CCCCCCCCCCCCCCC)=O)O3)C=C2)O1 |
| 分子式 | C32H48O8S |
| 分子量 | 592.8 |
| 溶解度 | DMF: 30 mg/mL,DMSO: 30 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is a fluorogenic substrate of palmitoyl-protein thioesterase (PPT, also known as CLN1), a lysosomal hydrolase that removes long-chain fatty acyl groups from modified cysteine residues in proteins. 4-Methylumbelliferyl 6-thio-palmitate-β-D-glucopyranoside is cleaved by PPT/CLN1 to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure PPT activity, which is commonly deficient in the neurodegenerative disorder known as infantile neuronal ceroid lipofuscinosis. |
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