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GLYX 13
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GLYX 13图片
CAS NO:117928-94-6
包装:1mg
市场价:924元

产品介绍
GLYX 13 (GLYX-13) 是一种 N-甲基-D-天冬氨酸受体 (NMDAR) 调节剂，具有甘氨酸位点部分激动剂的特性。
Cas No.117928-94-6
别名雷帕替奈; GLYX-13
化学名(S)-N-((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-1-((S)-1-((2S,3R)-2-amino-3-hydroxybutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamide
Canonical SMILESO=C([C@H]1N(C([C@H]([C@@H](C)O)N)=O)CCC1)N2[C@H](C(N[C@H](C(N)=O)[C@@H](C)O)=O)CCC2
分子式C18H31N5O6
分子量413.47
溶解度DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Target: NMDARapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic transmission in slices.

References:
[1]. Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11.