| CAS NO: | 145224-99-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 145224-99-3 |
| 别名 | Calcium-like Peptide 1 |
| 化学名 | (2S,3Z,5S,6Z,8S,9Z,11S,12Z,14S,15Z,17S,18Z,20S,21Z,23S)-23-amino-2-(4-aminobutyl)-17-((S)-sec-butyl)-4,7,10,13,16,19,22-heptahydroxy-14-((R)-1-hydroxyethyl)-8-isobutyl-5,11-diisopropyl-20,24-dimethyl-3,6,9,12,15,18,21-heptaazapentacosa-3,6,9,12,15,18,21-h |
| Canonical SMILES | CC[C@]([C@@](/N=C(O)/[C@](/N=C(O)/[C@](N)([H])C(C)C)([H])C)([H])/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=O)([H])CCCCN)([H])C(C)C)([H])CC(C)C)([H])C(C)C)([H])[C@@](O)([H])C)([H])C |
| 分子式 | C40H75N9O10 |
| 分子量 | 842.09 |
| 溶解度 | 0.5mg/mL in ethanol, 5mg/mL in DMF or in DMSO |
| 储存条件 | Desiccate at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CALP1 is an 8-residue calcium-like peptide that interacts with an EF hand motif based on the troponin C superfamily calcium binding site.[1] It binds to calmodulin (Kd = 88 μM) and activates phosphodiesterase in the presence of calmodulin and absence of calcium. CALP1 also acts as a cell-permeable inhibitor of calcium influx through glutamate receptor channels in cultured rat neocortical neurons thereby inhibiting excitatory cytotoxicity (IC50 = 52.48 μM) and apoptosis (IC50 = 44.78 μM).[2] CALP1 (1 mg/kg) pretreatment prevents increases in lung alveolar inflammatory cells after six, but not 24, hours in sensitized guinea pigs challenged with ovalbumin in a model of allergic asthma.[3] It also decreases radical production induced by phorbol 12-myristate 13-acetatein broncho-alveolar lavage cells after six and 24 hours and dose-dependently decreases histamine-induced hyperresponsiveness in isolated guinea pig tracheal rings. Reference: |
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