VEGFR-2/DHFR-IN-1

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VEGFR-2/DHFR-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

VEGFR-2/DHFR-IN-1 (compound 8b) 是VEGFR-2和DHFR的抑制剂，其IC₅₀值分别为 0.384 和 7.881 μM。VEGFR-2/DHFR-IN-1 对大肠埃希菌，粪链球菌，肠沙门氏菌，金黄色酿脓葡萄球菌，MSSA和MRSA显示了良好的抗菌活性，MIC值分别为 16，16，16，8 和 16 μg/mL。VEGFR-2/DHFR-IN-1 对 C26，HepG2 和 CF7 癌细胞系具有良好的细胞毒性，IC₅₀值为 2.97-7.12 μM。VEGFR-2/DHFR-IN-1 可用于癌症的研究。

生物活性

VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor ofVEGFR-2andDHFRwithIC₅₀s of 0.384 and 7.881 μM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities againstEscherichia coli,Streptococcus faecalis,Salmonella enterica,MSSAandMRSAwithMICvalues of 16, 16, 16, 8, and 16 μg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7cancercell lines withIC₅₀values of 2.97-7.12 μM. VEGFR-2/DHFR-IN-1 can be used for the research ofcancer^[1].

IC₅₀& Target

VEGFR-2

0.384 μM (IC₅₀)

DHFR

7.881 μM (IC₅₀)

体外研究
(In Vitro)

VEGFR-2/DHFR-IN-1 (2-1024 μg/mL; 18-72 h) shows antibacterial and antifungal activities with MIC values of 16, 64, 16, 16, 8, 16, 64 and 256 μg/mL forEscherichia coli,Pseudomonas aeruginosa,Streptococcus faecalis,Salmonella enterica,MSSA,MRSA,Candida albicansandAspergillus niger, respectively^[1].
VEGFR-2/DHFR-IN-1 (0.5-100 μM; 48 h) exhibits anticancer activities^[1].
VEGFR-2/DHFR-IN-1 (0-100 μM; 30 min) shows DHFR and VEGFR-2 inhibitory activities with IC₅₀s of 7.881 and 0.384 μM, respectively^[1].

Cell Cytotoxicity Assay^[1]

Cell Line:	C26, HepG2, MCF7 and H69PR cell lines
Concentration:	0.5, 1, 5, 10, 25, 50, 80 and 100 μM
Incubation Time:	48 hours
Result:	Showed anticancer activities to C26, HepG2, MCF7 and H69PR cells with IC₅₀s of 2.97, 7.12, 3.58 and 12.79 μM, respectively.

分子量

371.81

Formula

C₂₀H₁₈ClNO₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.