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IDT307
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IDT307图片
CAS NO:1141-41-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
IDT307 是有机阳离子 MPP+ 的类似物,是 DAT 的荧光底物 (荧光底物 APP+)。
Cas No.1141-41-9
Canonical SMILESC[N+]1=CC=C(C2=CC=C(N(C)C)C=C2)C=C1.[I-]
分子式C14H17IN2
分子量340.2
溶解度DMSO : 62.5 mg/mL (183.72 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IDT307, an analog of the organic cation MPP+, is a specific fluorescent substrate for DAT (fluorescent substrate APP+)[1].

IDT307, an analog of the organic cation MPP+, is transported into CP epithelial cells at the apical (CSF-facing) membrane and sensitive to inhibition by the PMAT inhibitor quinine[1].IDT307 uptake and intracellular accumulation is greatly attenuated by ~70% in CP tissue from the Pmat knockout mouse[1].

References:
[1]. Tao Hu, et al. Molecular mechanisms of organic cation and anion transport at the blood‐CSF barrier. 01 April 2018.