您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > NADP+
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
NADP+
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NADP+图片
CAS NO:53-59-8
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议
1g电议

产品介绍
Cas No.53-59-8
别名烟酰胺腺嘌呤双核苷酸磷酸盐,Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN
化学名adenosine 5'-(trihydrogen diphosphate), 2'-(dihydrogen phosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, inner salt
Canonical SMILESO[C@H]1[C@@H](OP(O)(O)=O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP(OP(OC[C@@H]4[C@@H](O)[C@@H](O)[C@H]([N+]5=CC(C(N)=O)=CC=C5)O4)([O-])=O)(O)=O
分子式C21H28N7O17P3
分子量743.4
溶解度Soluble in PBS, PH7.2, 10mg/mL
储存条件Store at -20°C,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NADP+ is the oxidized form of the electron donor nicotinamide adenine dinucleotide phosphate. NADP+ together with its reduced form, reduced NADPH, is involved in maintaining redox balance and supporting the biosynthesis of fatty acids and nucleic acids[1].

NADP+, a structural analogue of NAD+, is synthesized by transferring a phosphate group from ATP to the 2′-hydroxyl group of the adenosine ribose moiety of NAD+. This reaction is catalyzed by NADKs[2]. NADP+ act as a cofactor in various biological reactions[3]. NADP+/NADPH is important in regulating the cellular redox state, energy metabolism, mitochondrial function, gene expression, and signaling pathways, NADP+/NADPH are essential for maintaining a large array of biological processes[3,4,5].

References:
[1]. Yang, Yue, and Anthony A. Sauve. "NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy." Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1864.12 (2016): 1787-1800.
[2]. Ying, Weihai. "NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences." Antioxidants & redox signaling 10.2 (2008): 179-206.
[3]. Jackson J B. A review of the binding-change mechanism for proton-translocating transhydrogenase[J]. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2012, 1817(10): 1839-1846.
[4]. CantO, Carles, and Johan Auwerx. "NAD+ as a signaling molecule modulating metabolism." Cold Spring Harbor symposia on quantitative biology. Vol. 76. Cold Spring Harbor Laboratory Press, 2011.
[5]. CantO, Carles, Keir J. Menzies, and Johan Auwerx. "NAD+ metabolism and the control of energy homeostasis: a balancing act between mitochondria and the nucleus." Cell metabolism 22.1 (2015): 31-53.