Cas No. | 118427-55-7 |
Canonical SMILES | CC(C)(C([O-])=O)CC1=C(SC(C)(C)C)C2=CC(C(C)C)=CC=C2N1CC3=CC=C(Cl)C=C3.[Na+] |
分子式 | C27H33ClNO2S•Na |
分子量 | 494.1 |
溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): .2 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Arachidonic acid and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO). The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active. MK-886 binds to FLAP with high-affinity and prevents 5-LO activation. MK-886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM. In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM. |