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MitoPQ
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MitoPQ图片
CAS NO:1821370-28-8
包装与价格：
包装价格(元)
5mg电议
25mg电议

产品介绍
MitoPQ 是一种线粒体靶向氧化还原循环仪。 MitoPQ 通过复合物 I 的黄素位点的氧化还原循环产生超氧化物，选择性地增加线粒体内的超氧化物产生。 MitoPQ 可用于抗氧化研究。
Cas No.1821370-28-8
别名MitoParaquat
化学名1-methyl-1'-(10-(triphenylphosphonio)decyl)-[4,4'-bipyridine]-1,1'-diium iodide
Canonical SMILESC[N+](C=C1)=CC=C1C(C=C2)=CC=[N+]2CCCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[I-].[I-].[I-]
分子式C39H46N2P o 3I
分子量954.5
溶解度10mM in ethanol or 100mM in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.[1] Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I.[1] Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.[1]

Reference:
[1]. Robb, E.L., Gawel, J.M., Aksentijevic, D., et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology & Medicine 89, 883-894 (2015).