包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
5mg | 电议 |
25mg | 电议 |
100mg | 电议 |
BV6 是凋亡抑制剂 (IAP) 家族成员 cIAP1 和 XIAP 的拮抗剂。
Cell lines | HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. |
Preparation method | Limited solubility. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months. |
Reaction Conditions | 37℃ |
Applications | BV6 reduces the expression of cIAP1 and XIAP in HCC193 and H460 cell lines in a time and dose-dependent manner. BV6 also induces apoptosis in both HCC193 and H460 cell lines. In addition, BV6 prominently promotes the radiosensitivity of both HCC193 and H460 lung cancer cell lines. |
Animal models | Mouse endometriosis model |
Dosage form | Single i.p. injection of BV6 (10 mg/kg) twice weekly. |
Applications | BV6 treatment for 4 weeks attenuates the intensity of IAPs expression and lowers the total number of lesions, the average weight and the surface area of lesions as compared with control group. Moreover, BV6 treatment decreases the percentage of Ki67-positive cells in the endometrial gland epithelia or stroma. |
Other notes | Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal. |
产品描述 | BV6 is a selective inhibitor of IAP family with IC50 value of 7.2 μM when tested with H460 cells [1]. |