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Ambroxol hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ambroxol hydrochloride图片
CAS NO:23828-92-4
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
100mg电议
200mg电议
500mg电议

产品名称
盐酸氨溴索
NA-872 hydrochloride
产品介绍
Ambroxol hydrochloride (NA-872 hydrochloride) 是前药溴己辛的活性代谢产物,具有强效祛痰作用。Ambroxol hydrochloride 是一种葡糖脑苷脂酶 (GCase) 伴侣,可增加葡糖脑苷脂酶的活性。Ambroxol hydrochloride 可诱导肺自噬,并有用于帕金森氏病和神经性戈谢病研究的潜力。
生物活性

Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is aglucocerebrosidase (GCase)chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lungautophagyand has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

体内研究
(In Vivo)

Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein[2].

Clinical Trial
分子量

414.56

性状

Solid

Formula

C13H19Br2ClN2O

CAS 号

23828-92-4

中文名称

盐酸氨溴索

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 8.33 mg/mL(20.09 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.4122 mL12.0610 mL24.1220 mL
5 mM0.4824 mL2.4122 mL4.8244 mL
10 mM0.2412 mL1.2061 mL2.4122 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。