Cystamine(dihydrochloride)

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

56-17-7

包装与价格：

包装	价格(元)
10 g	电议
50 g	电议

产品介绍

Cystamine (dihydrochloride) 是游离硫醇半胱胺的二硫化物形式。Cystamine 是一种转谷氨酰胺酶 (Tgase) 抑制剂，具有口服活性。Cystamine 对 caspase-3 也有抑制活性，IC₅₀值为 23.6 μM。Cystamine 可用于亨廷顿舞蹈病（HD）等多种疾病的研究。

生物活性

Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally activetransglutaminase (Tgase)inhibitor. Cystamine also has inhibition activity for caspase-3 with anIC₅₀value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)^[1]^[2]^[3].

IC₅₀& Target^[1]

Caspase 3

23.6 μM (IC₅₀)

体外研究
(In Vitro)

Cystamine (dihydrochloride) has inhibition activity for caspase-3 with an IC₅₀value of 23.6 μM^[1].
Cystamine (0-500 μM; 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner^[1].
Cystamine (250 μM; 10 h) robustly increases the levels of glutathione^[1].

Western Blot Analysis^[1]

Cell Line:	Human neuroblastoma SH-SY5Y cells
Concentration:	250, 500 μM
Incubation Time:	0-16 h
Result:	Inhibited the MG132-mediated activation of caspase-3. Inhibited the H2O2-mediated activation of caspase-3. Inhibited caspase-3 activity in a tTG-independent manner.

体内研究
(In Vivo)

Cystamine (dihydrochloride) (oral, i.p.; 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice^[2].

Animal Model:	R6/2 transgenic HD mice^[2]
Dosage:	112, 225 mg/kg
Administration:	Intraperitoneal or oral, daily
Result:	Significantly extended survival, improved body weight and motor performance, delayed the neuropathological sequela and significantly altered the levels of Tgase activity and N(Sigma)-(gamma-L-glutamyl)-L-lysine (GGEL) levels.

分子量

225.20

性状

Solid

Formula

C₄H₁₄Cl₂N₂S₂

CAS 号

56-17-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)