HLF1-11

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HLF1-11

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

183623-03-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

HLF1-11，一种人乳铁蛋白衍生肽，是一种广谱抗菌剂。HLF1-11 抑制MPO(human) 的活性。HLF1-11 还使 GM-CSF 驱动的单核细胞向巨噬细胞分化，并增强其免疫反应。

生物活性

HLF1-11, a human lactoferrin-derived peptide, is a broad spectrumantimicrobialagent. HLF1-11 inhibits humanMPOactivity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses^[1]^[2].

体外研究
(In Vitro)

hLF1-11 (1, 10, and 100 μg/mL) directs differentiation of monocytes toward a macrophage subset during granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven monocytes differentiation^[2].
hLF1-11 (0.5-250 μg/mL) inhibits human MPO activity^[3].
hLF1-11 (100 μg/mL, 90 min) inhibits ROS induction induced by LPS in monocytes^[3].
hLF1-11 (8-34 μΜ, 2 h) is active against fluconazole-resistantC. albicans^[5].

体内研究
(In Vivo)

hLF1-11 (20 mg/kg, injected into the debrided tibial cavity) shows ability against MRSA osteomyelitis in rabbits^[4].
hLF1-11 (40 μg/kg, i.v.) is active againstC. albicans-infected mice^[6].

Animal Model:	Rabbits inoculated with CFU MRSA^[4]
Dosage:	20 mg/kg
Administration:	Injected into the debrided tibial cavity
Result:	Reduced bacterial load compared to controls, and reduced the radiological and histopathological score.

Animal Model:	Neutropenic mice challenged i.v. withC. albicans
Dosage:	40 μg/kg
Administration:	Intravenous injection (i.v)
Result:	Reduced serum TNFα and IL-6 in infected mice.

Clinical Trial

分子量

1374.58

Formula

C₅₆H₉₅N₂₅O₁₄S

CAS 号

183623-03-2

Sequence Shortening

GRRRRSVQWCA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.