Simvastatin acid

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Simvastatin acid

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

121009-77-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Tenivastatin

产品介绍

Simvastatin acid (Tenivastatin)，Simvastatin (HY-17502) 的水解产物，是一种有效的 HMG-CoA 还原酶 (HMGCR) 抑制剂。Simvastatin acid 降低吲哚酚硫酸盐 (Indoxyl sulfate) 介导的活性氧 (ROS) 产生。Simvastatin acid 也可调节心肌细胞和转染 OATP3A1 基因的 HEK293 细胞的 OATP3A1 表达。

生物活性

Simvastatin acid (Tenivastatin), a hydrolysate ofSimvastatin(HY-17502), is aHMG-CoA reductase(HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediatedreactive oxygen species(ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene^[1]^[2].

IC₅₀& Target

HMG-CoA reductase, Reactive oxygen species^[1]^[2]

体外研究
(In Vitro)

Simvastatin acid (0.1-20 μM; 24 h) significantly decreases ROS production between 8.9% and 43% in Indoxyl sulfate-treated hCM cells^[2].
Simvastatin acid (0.1-20 μM; 24 h) alters the protein expression of OATP3A1 in hCMs and OATP3A1-expressing HEK293 cells^[2].

Western Blot Analysis^[2]

Cell Line:	hCM and HEK293 (transfected with OATP3A1)
Concentration:	0.1, 1, 10 and 20 μM
Incubation Time:	24 h
Result:	Decreased 1.5% to 90% in OATP3A1 expression with a dose-dependent manner in both hCMs and OATP3A1-expressing cells.

分子量

436.58

Formula

C₂₅H₄₀O₆

CAS 号

121009-77-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.