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Indoximod
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Indoximod图片
CAS NO:110117-83-4
包装与价格:
包装价格(元)
250mg电议
500mg电议
1 g电议

产品名称
1-Methyl-D-tryptophan
NLG-8189
产品介绍
Indoximod (1-Methyl-D-tryptophan) 是一种具有口服活性的吲哚胺2,3-双加氧酶(IDO) 途径抑制剂。Indoximod 充当Trp模拟物,调节mTOR中。Indoximod 是一种可用于癌症研究的免疫代谢佐剂。
生物活性

Indoximod (1-Methyl-D-tryptophan) is an orally activeindoleamine 2,3-dioxygenase(IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulatingmTOR. Indoximod is an immunometabolic adjuvant used for the research ofcancer[1][2].

IC50& Target[1]

IDO

19 μM (Ki)

体外研究
(In Vitro)

The IDO inhibitor 1-methyl-tryptophan exists in two stereoisomers with potentially different biological properties. The L isomer is the more potent inhibitor of IDO activity using the purified enzyme and in HeLa cell–based assays. However, the D isomer is significantly more effective in reversing the suppression of T cells created by IDO-expressing dendritic cells. The L isomer of 1-methyl-tryptophan functioned as a competitive inhibitor (Ki=19 μM), whereas the d isomer is much less effective. The DL mixture is intermediate, with a Kiof 35 μM[1].

体内研究
(In Vivo)

The D isomer is more efficacious as an anticancer agent in chemo-immunotherapy regimens using NSC-26271, NSC 125973, or LY 188011, when tested in mouse models of transplantable melanoma and transplantable and autochthonous breast cancer. The D isomer of 1-methyl-tryptophan specifically targets the IDO gene because the antitumor effect of d-1-methyl-tryptophan is completely lost in mice with a disruption of the IDO gene (IDO-knockout mice). Oral administration of dl-1-methyl-tryptophan in combination with NSC 125973 can elicit regression of autochthonous breast tumors[1].

Clinical Trial
分子量

218.25

性状

Solid

Formula

C12H14N2O2

CAS 号

110117-83-4

中文名称

1-甲基-D-色氨酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : 5 mg/mL(22.91 mM;ultrasonic and adjust pH to 2 with HCl)

DMSO : 0.55 mg/mL(2.52 mM;Need ultrasonic and warming)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.5819 mL22.9095 mL45.8190 mL
5 mM0.9164 mL4.5819 mL9.1638 mL
10 mM0.4582 mL2.2910 mL4.5819 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 1 mg/mL (4.58 mM); Clear solution; Need ultrasonic and warming and heat to 60℃

*以上所有助溶剂都可在本网站选购。