CAS NO: | 110117-83-4 |
包装 | 价格(元) |
250mg | 电议 |
500mg | 电议 |
1 g | 电议 |
生物活性 | Indoximod (1-Methyl-D-tryptophan) is an orally activeindoleamine 2,3-dioxygenase(IDO) pathway inhibitor. Indoximod acts as a Trp mimetic in regulatingmTOR. Indoximod is an immunometabolic adjuvant used for the research ofcancer[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | The IDO inhibitor 1-methyl-tryptophan exists in two stereoisomers with potentially different biological properties. The L isomer is the more potent inhibitor of IDO activity using the purified enzyme and in HeLa cell–based assays. However, the D isomer is significantly more effective in reversing the suppression of T cells created by IDO-expressing dendritic cells. The L isomer of 1-methyl-tryptophan functioned as a competitive inhibitor (Ki=19 μM), whereas the d isomer is much less effective. The DL mixture is intermediate, with a Kiof 35 μM[1]. | ||||||||||||||||
体内研究 (In Vivo) | The D isomer is more efficacious as an anticancer agent in chemo-immunotherapy regimens using NSC-26271, NSC 125973, or LY 188011, when tested in mouse models of transplantable melanoma and transplantable and autochthonous breast cancer. The D isomer of 1-methyl-tryptophan specifically targets the IDO gene because the antitumor effect of d-1-methyl-tryptophan is completely lost in mice with a disruption of the IDO gene (IDO-knockout mice). Oral administration of dl-1-methyl-tryptophan in combination with NSC 125973 can elicit regression of autochthonous breast tumors[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 218.25 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H14N2O2 | ||||||||||||||||
CAS 号 | 110117-83-4 | ||||||||||||||||
中文名称 | 1-甲基-D-色氨酸 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: H2O : 5 mg/mL(22.91 mM;ultrasonic and adjust pH to 2 with HCl) DMSO : 0.55 mg/mL(2.52 mM;Need ultrasonic and warming) 配制储备液
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