ZC0109

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ZC0109

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

ZC0109 是IDO1和硫氧还蛋白还原酶 1 (TrxR1) 的双抑制剂，IC₅₀分别为 50 nM 和 3.0 μM。ZC0109 诱导活性氧 (ROS) 积累，使细胞周期阻滞于 G1/S 期，导致癌细胞凋亡 (apoptosis)。

生物活性

ZC0109 is a dual inhibitor ofIDO1andthioredoxin reductase 1(TrxR1) withIC₅₀s of 50 nM and 3.0 μM, respectively. ZC0109 induces ROS accumulation and cell cycle arrest at G1/S phase, thus leads tocancercellsapoptosis^[1].

IC₅₀& Target

IC50: 50 nM (IDO1), 3.0 μM (TrxR1)^[1]

体外研究
(In Vitro)

ZC0109 (24 h) inhibits cancer cells with IC₅₀s of 3.44 μM (HCT-116), 12.4 μM (CT26), and 10.2 μM (HeLa), respectively^[1].
ZC0109 (2.5-10 μM; 24 h) induces ROS accumulation in HCT-116 and HeLa cells^[1].
ZC0109 (2.5-10 μM; 24 h) induces apoptosis and G1/S cell cycle arrest in cancer cell^[1].

Cell Cycle Analysis^[1]

Cell Line:	HCT-116 cells and HeLa cells
Concentration:	2.5 μM, 5 μM, and 10 μM
Incubation Time:	24 hours
Result:	Arrested cell cycle at G1/S phase.

体内研究
(In Vivo)

ZC0109 (15, 30, and 60 mg/kg; p.o.; once daily for 28 d) reduces Kyn/Trp metabolism in C57BL/6 mice^[1].
ZC0109 (60 mg/kg; p.o.; once daily for 28 d) decreases tumor growth and increases accumulation and infiltration of T cells in CT-26 cells transplanted immunocompetent BALB/c mice^[1].

分子量

591.41

Formula

C₂₂H₂₀BrFN₈O₄S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.