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(Rac)-Indoximod
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(Rac)-Indoximod图片
CAS NO:26988-72-7
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
50mg电议
100mg电议
200mg电议

产品名称
1-Methyl-DL-tryptophan
(Rac)-NLG-8189
产品介绍
(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(Rac)-Indoximod 和 IFN-γ 联用显著降低了表达 α-SMA 的人心肌成纤维细胞活性,并通过上调 IRF-1,Fas 和 FasL 基因诱导凋亡(apoptosis)。
生物活性

(Rac)-Indoximod (1-Methyl-DL-tryptophan) is anindoleamine 2,3-dioxygenase(IDO) inhibitor. Co-treatment withIFN-γand (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and inducesapoptosisthrough up-regulating the IRF-1,Fas, and FasL genes[1].

IC50& Target[1]

IDO

 

体外研究
(In Vitro)

(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion[1].

Cell Viability Assay[1]

Cell Line:Human cardiac myofibroblasts (hCMs)
Concentration:0.5 mM
Incubation Time:3 days
Result:Growth retardation by IFN-γ was partially reversed on day 2, but cell viability was further reduced on day 3.
分子量

218.25

性状

Solid

Formula

C12H14N2O2

CAS 号

26988-72-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

0.1 M NaOH : 10 mg/mL(45.82 mM;Need ultrasonic)

DMSO : 4.76 mg/mL(21.81 mM;ultrasonic and warming and adjust pH to 4 with HCl and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.5819 mL22.9095 mL45.8190 mL
5 mM0.9164 mL4.5819 mL9.1638 mL
10 mM0.4582 mL2.2910 mL4.5819 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。