CAS NO: | 26988-72-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
生物活性 | (Rac)-Indoximod (1-Methyl-DL-tryptophan) is anindoleamine 2,3-dioxygenase(IDO) inhibitor. Co-treatment withIFN-γand (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and inducesapoptosisthrough up-regulating the IRF-1,Fas, and FasL genes[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | (Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion[1]. Cell Viability Assay[1]
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分子量 | 218.25 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H14N2O2 | ||||||||||||||||
CAS 号 | 26988-72-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: 0.1 M NaOH : 10 mg/mL(45.82 mM;Need ultrasonic) DMSO : 4.76 mg/mL(21.81 mM;ultrasonic and warming and adjust pH to 4 with HCl and heat to 60℃) 配制储备液
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