CAS NO: | 1432660-47-3 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | AGI-6780 that potently and selectively inhibits the tumor-associated mutantIDH2R140QwithIC50of 23±1.7 nM. AGI-6780 is less potent againstIDH2WTwithIC50of 190±8.1 nM. | ||||||||||||||||
IC50& Target | IC50: 23±1.7 nM (IDH2R140Q), 190±8.1 nM (IDH2WT)[1] | ||||||||||||||||
体外研究 (In Vitro) | AGI-6780 is tested in both human glioblastoma U87 and TF-1 cells expressing IDH2R140Q, as well as against IDH1R132Hfor 48 h incubation, with IC50 of 11±2.6 nM, 18±0.51 nM, and >1 mM, respectivly.Treatment of TF-1R140Qcells with AGI-6780, at concentrations that lower 2HG to near-normal physiologic levels, restore expression of both HBG and KLF1 genes and the color change associated with differentiation. AGI-6780 can reverse the IDH2R140Q-induced differentiation block in TF-1 cells. Pretreatment with AGI-6780 (0.2 μM and 1 μM) markedly decreased the intracellular concentration of (R)-2-hydroxyglutarate in the TF1R140Qcells and restored their ability to undergo EPO-induced differentiation[1]. | ||||||||||||||||
分子量 | 481.51 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H18F3N3O3S2 | ||||||||||||||||
CAS 号 | 1432660-47-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 29 mg/mL(60.23 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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