CAS NO: | 1429179-07-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor ofisocitrate dehydrogenase1 (IDH1). IDH889 has potent selectivity forIDH1R132* mutations, withIC50s of 0.02 μM, 0.072 μM and 1.38 μM forIDH1R132H,IDH1R132CandIDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50of 0.014 μM[1]. | ||||||||||||||||
IC50& Target | IC50: 0.02 μM (IDH1R132H), 0.072 μM (IDH1R132C), 1.38 μM (IDH1wt)[1] | ||||||||||||||||
分子量 | 436.48 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H25FN6O2 | ||||||||||||||||
CAS 号 | 1429179-07-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 200 mg/mL(458.21 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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