Sacubitril-13C4 (AHU-377-13C4) hemicalcium salt is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potentNEPinhibitor with anIC₅₀of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

434.49

C₂₀¹³C₄H₂₈Ca_0.5NO₅

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.