CAS NO: | 1190221-43-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), hasIC50values between 13.9 and 51.1 μM and induces intrinsicapoptosisin several humancancercell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2]. | ||||||||||||||||
IC50& Target | IC50: 13.9~51.1 μM (Tumor cell lines)[1] | ||||||||||||||||
体外研究 (In Vitro) | TM5441 dose-dependently decreases HT1080, HCT116, Daoy, MDA-MB-231 and Jurkat cells with an IC50ranging between 13.9 and 51.1 μM[1]. | ||||||||||||||||
体内研究 (In Vivo) | Oral administration of TM5441 (20 mg/kg daily) to HT1080 and HCT116 xenotransplanted mice increases tumor cell apoptosis and has a significant disruptive effect on the tumor vasculature that is associated with a decrease in tumor growth and an increase in survival. The average peak plasma concentration is 11.4 μM one hour after oral administration and undetectable levels 23 hours after administration[1]. | ||||||||||||||||
分子量 | 428.82 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H17ClN2O6 | ||||||||||||||||
CAS 号 | 1190221-43-2 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 300 mg/mL(699.59 mM) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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