Anecortave Acetate

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Anecortave Acetate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

7753-60-8

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Anecortave

产品介绍

Anecortave acetate 是一种有效的眼部血管抑制剂。Anecortave acetate 抑制由许多不同的血管生成因子诱导的新血管形成，也能增加纤溶酶原激活物抑制子 1 (PAI-1) mRNA表达。Anecortave acetate 可用于研究眼部新生血管疾病。

生物活性

Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases^[1]^[2].

IC₅₀& Target

PAI-1^[2]

体内研究
(In Vivo)

Anecortave acetate (5 μl of a 10% suspension; Injected into eyes) significantly inhibits pathologic retinal angiogenesis and increases PAI-1 mRNA levels^[2].

Animal Model:	Sprague-Dawley albino rats (intravitreally injected with premixed antibiotics to influence retinal vessel growth)^[2]
Dosage:	5 μl of a 10% suspension of Anecortave acetate
Administration:	Injected into eyes
Result:	significantly inhibited pathologic retinal angiogenesis in this model, while not significantly affecting normal intraretinal vessels. Increased 6-to-9-fold PAI-1 mRNA at 1 to 3 days after injection.

Clinical Trial

分子量

386.48

Formula

C₂₃H₃₀O₅

CAS 号

7753-60-8

中文名称

δ-9(11)-氢化可的松醋酸酯

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.