Calyculin A

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Calyculin A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

101932-71-2

包装与价格：

包装	价格(元)
10 μg (0.5 mM * 20 μL in DMSO)	电议
25 μg (0.5 mM * 50 μL in DMSO)	电议
50 μg (0.5 mM * 100 μL in DMSO)	电议
100 μg (0.5 mM * 200 μL in DMSO)	电议

产品名称

(-)-Calyculin A

产品介绍

Calyculin A ((-)-Calyculin A) 是有效，可渗透细胞的蛋白磷酸酶 1 (PP1) 和蛋白磷酸酶 2A (PP2A) 抑制剂，其IC₅₀值分别为 2 nM 和 0.5-1 nM。

生物活性

Calyculin A ((-)-Calyculin A) is a potent and cell-permeable proteinphosphatase1 (PP1) and proteinphosphatase2A (PP2A) inhibitor withIC₅₀s of 2 nM and 0.5-1 nM, respectively^[1].

IC₅₀& Target

IC50: 2 nM (PP1); 0.5-1 nM (PP2A)^[1]

体外研究
(In Vitro)

Calyculin A (1-10 nM; 24 hours) induces cytotoxicity in MG63 cells in a dose-dependent manner up to 10 nM in MG63 cells^[2].

Cell Cytotoxicity Assay^[2]

Cell Line:	Human osteosarcoma MG63 cells
Concentration:	0, 1, 2, 5, 10 nM
Incubation Time:	24 hours
Result:	Treatment with 0.1 nM for 24 h had a minimal effect on MG63 cell survival. Cell rounding and shrinking were obvious in the cultures treated for 24 h with 5 nM. The level of the cell viability treated with 10 nM was 27% that of the control cultures.

分子量

1009.17

性状

Liquid

Formula

C₅₀H₈₁N₄O₁₅P

CAS 号

101932-71-2

中文名称

花萼海绵诱癌素；花萼海绵体诱癌素A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Solution, -20°C, 2 years