BR102910

立即咨询

BR102910

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2505339-54-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

BR102910 是一种选择性的成纤维细胞活化蛋白 (FAP) 抑制剂，IC₅₀为 2 nM。BR102910 还抑制脯氨酰寡肽酶 (PREP)，IC₅₀为 49.00 μM。BR102910可用于2型糖尿病的研究。

生物活性

BR102910 is a selective fibroblast activation protein (FAP) inhibitor with theIC₅₀of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC₅₀of 49.00 μM. BR102910 can be used for the researchof type 2

IC₅₀& Target

IC50: 2 nM (FAP), 49.0 μM (PREP), >100 μM (DPP-4)^[1]

体内研究
(In Vivo)

BR102910 (C57BL/6J mice, 0-30 mg/kg, Orally, once) shows significant FAP inhibition in a dose dependent manner^[1].

Animal Model:	C57BL/6J mice (n = 5 per group)^[1]
Dosage:	0, 10 and 30 mg/kg
Administration:	Orally, once
Result:	Showed significant FAP inhibition in a dose dependent manner.

分子量

459.30

性状

Solid

Formula

C₁₈H₁₄Cl₂F₂N₄O₂S

CAS 号

2505339-54-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)