PKM2 activator 2 is apyruvate kinaseM2(PKM2) activitor with anAC₅₀value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells^[1].

PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines^[1].
PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC₅₀value of 66 nM in the luciferase-coupled assay^[1].

452.49

C₂₀H₁₈F₂N₂O₄S₂

1186660-06-9

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