Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent^[1].

Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC₅₀of Alkannin is 0.3 μM. In the presence of FBP (125 μM), the IC₅₀of Alkannin is 0.9 μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2^[1].
Alkannin (2.5-20 μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption^[1].

288.30

C₁₆H₁₆O₅

23444-65-7

• Quinones
• Naphthalene Quinones

• Phenols
• Monophenols

• Plants
• Leguminosae
• Ohwia caudata(Thunberg) H. Ohashi

• Plants
• Compositae

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.