Remikiren

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Remikiren

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

126222-34-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Ro 42-5892
Ro 42-5892/001

产品介绍

Remikiren (Ro 42-5892) 是一种口服有效的、高特异性的肾素抑制剂。Remikiren 能特异性地抑制人肾素和人血浆肾素，其IC₅₀值分别为 0.7 和 0.8 nM。Remikiren 还能降低钠耗竭的狨猴和松鼠猴的平均动脉血压。Remikiren 可用于高血压的研究。

生物活性

Remikiren (Ro 42-5892) is an orally active and highly specificrenininhibitor. Remikiren specifically inhibits humanreninand human plasmareninwithIC₅₀values of 0.7 and 0.8 nM, respectively. Remikiren also reduces mean arterial blood pressure in sodium-depleted marmosets and squirrel monkeys. Remikiren can be used in study of hypertension^[1].

IC₅₀& Target

IC50:0.7 nM (human pure renin), 0.8 nM (plasma renin of human)^[1].

体外研究
(In Vitro)

Remikiren (0-10 nM; 1-3 h) displays a considerable specificity to inhibit renin^[1].

Cell Viability Assay^[1]

Cell Line:	Human pure renin, plasma renin of human, marmoset, squirrel monkey
Concentration:	0-10 nM
Incubation Time:	1-3 h
Result:	Inhibited human pure renin and plasma renin of human, marmoset, squirrel monkey with IC₅₀values of 0.7, 0.8, 1.0 and 1.7 nM, respectively.

体内研究
(In Vivo)

Remikiren (0.1, 0.3, 1, 3, 10 mg/kg; p.o.; single) reduces mean arterial blood pressure in a dose-dependent manner in sodium-depleted marmosets and squirrel monkeys^[1].
Remikiren (3 mg/kg; p.o.; single) shows the duration of blood pressure decrease more than 24 h in sodium-depleted marmosets^[1].

Animal Model:	Marmosets and squirrel monkeys (sodium-depleted)^[1].
Dosage:	0.1, 0.3, 1, 3, 10 mg/kg
Administration:	Oral administration; single.
Result:	Decreased mean arterial pressure (MAP) by 20-25 mm Hg when at 0.1 mg/kg. Reached the maximal decrease (30 mm Hg) of MAP with 1 mg/kg in marmosets. Decreasesd 35 mm Hg blood pressure with 3-10 mg/kg in squirrel monkeys.

Animal Model:	Marmosets (sodium-depleted)^[1].
Dosage:	3 mg/kg
Administration:	Oral administration; single.
Result:	Showed MAP fell by 30 mm Hg, which lasting more than 24 h.

分子量

630.84

Formula

C₃₃H₅₀N₄O₆S

CAS 号

126222-34-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.