SR12418

立即咨询

SR12418

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1801185-08-9

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SR12418 是一种REV-ERB特异性合成配体，对 REV-ERBα 和 REV-ERBβ 的IC₅₀值分别为 68 nM 和 119 nM。SR12418 可用于实验性自身免疫性脑脊髓炎 (EAE) 和结肠炎的研究。

生物活性

SR12418 is aREV-ERB-specific synthetic ligandwithIC₅₀s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research^[1]^[2].

IC₅₀& Target

IC50: 68 nM (REV-ERBα) and 119 nM (REV-ERBβ)^[1]

体外研究
(In Vitro)

SR12418 (5 μM; 96 h) inhibits the growth of TH17 cells^[1].
SR12418 (5 and 10 μM; 4 d) inhibits cell differentiation under TH17 polarizing conditions^[1].

RT-PCR^[1]

Cell Line:	TH17 cells
Concentration:	5 μM
Incubation Time:	96 hours
Result:	Repressed TH17-mediated gene expression andNfil3.

Cell Differentiation Assay^[1]

Cell Line:	Mouse CD4⁺T cells
Concentration:	5 and 10 μM
Incubation Time:	4 days
Result:	Inhibited TH17 cell differentiation in a dose-dependent manner.

体内研究
(In Vivo)

SR12418 (intraperitoneal injection; 50 mg/kg; twice a day) suppresses the development and severity of experimental autoimmune encephalomyelitis^[1].
SR12418 (intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization) shows effects in intervention studies of relapsing-remitting experimental autoimmune encephalomyelitis^[1].

Animal Model:	C57BL/6 mice inducing experimental autoimmune encephalomyelitis (EAE)^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; 50 mg/kg; twice a day
Result:	Diminished the incidence of disease with approximately 20% mice developing disease. Showed no overt signs of toxicity.

Animal Model:	PLP139-151-induced relapsing-remitting EAE (R-EAE) in SJL/J mice^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization
Result:	Resulted in a significant reduction in the relapse severity compared to the vehicle control. Showed a significant decrease in the frequency and number of CD4⁺and CD8⁺effector cells (CD44^hi).

分子量

483.57

Formula

C₃₁H₃₀FNO₃

CAS 号

1801185-08-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.