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Loxistatin Acid(E-64C NSC694279 EP475)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loxistatin Acid(E-64C NSC694279 EP475)图片
CAS NO:76684-89-4
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)314.38
FormulaC15H26N2O5
CAS No.76684-89-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 62 mg/mL (197.2 mM)
Water: 2 mg/mL (6.4 mM)
Ethanol: 62 mg/mL (197.2 mM)
Solubility (In vivo)Saline: 2mg/mL
SynonymsNSC-694279; EP-475; E64-C; NSC 694279; EP 475; E64 C; NSC694279; EP475; E64C; Loxistatin Acid;
实验参考方法
In Vitro

In vitro activity: Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease.

In VivoIn pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats.
Animal modelMale Sprague-Dawley rats.
Formulation & DosageDissolved in a small amount of saturated bicarbonate solution and then diluted with 0.9% NaCl saline; 400 mg/kg; i.p. injection
References

Biochem Biophys Res Commun. 1989 Jan 31;158(2):432-5; J Neurosci Res. 2003 Nov 1;74(3):393-405; J Biol Chem. 1991 Aug 5;266(22):14771-7.