PF-4950834

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PF-4950834

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1256264-62-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PF-4950834 是一种有效的、选择性的、具有口服活性的、ATP竞争性的rho kinase抑制剂，对 ROCK2 和 ROCK1 的IC₅₀分别为 8.35 nM 和 33.12 nM。PF-4950834 抑制中性粒细胞迁移。

生物活性

PF-4950834 is a potent, selective, orally bioavailable, ATP-competitiverho kinaseinhibitor withIC₅₀values of 8.35 nM and 33.12 nM againstROCK2andROCK1, respectively. PF-4950834 inhibits neutrophil migration^[1].

IC₅₀& Target

ROCK2

8.35 nM (IC₅₀)

ROCK1

33.12 nM (IC₅₀)

PKCη

756 nM (IC₅₀)

PKA

424 nM (IC₅₀)

体外研究
(In Vitro)

PF-4950834 shows inhibition against the AGC (cAMP-dependent protein kinase/protein kinase G/protein kinase C) kinase family with IC₅₀values of 8.35, 33.12, 102, 216, 321, 384, 411, 424, 457, 578, 736, 756 and 2900 nM for ROCK2, ROCK1, PRKG1, PKN1, SGK2, PRKG2, MSK1, PKA, PRKX, MSK2, P70S6K, PKC_ηand SGK1, respectively^[1].

分子量

345.39

Formula

C₂₁H₁₉N₃O₂

CAS 号

1256264-62-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.