CAS NO: | 675126-08-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Dasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor that blocksdopamine,norepinephrine, andserotonintransporters withIC50values of 4, 6, and 11 nM, respectively. | ||||||||||||||||
IC50& Target | IC50: 4 nM (dopamine), 6 nM (norepinephrine), 11 nM (serotonin)[1] | ||||||||||||||||
体内研究 (In Vivo) | Acute administration of dasotraline dose-dependently decreases the spontaneous firing rate of LC NE, VTA DA and DR 5-HT neurons through the activation of α2, D2 and 5-HT1A autoreceptors, respectively. Dasotraline predominantly inhibits the firing rate of LC NE neurons while producing only a partial decrease in VTA DA and DR 5-HT neuronal discharge. SEP-225289 is equipotent at inhibiting 5-HT and NE transporters since it prolongs to the same extent the time required for a 50% recovery of the firing activity of dorsal hippocampus CA3 pyramidal neurons from the inhibition induced by microiontophoretic application of 5-HT and NE[1]. Average dopamine and serotonin transporter occupancies increase with increasing doses of SEP-225289. Mean dopamine and serotonin transporter occupancies are 33%±11% and 2%±13%, respectively, for 8 mg; 44%±4% and 9%±10%, respectively, for 12 mg; and 49%±7% and 14%±15%, respectively, for 16 mg[2]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 328.66 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H16Cl3N | ||||||||||||||||
CAS 号 | 675126-08-6 | ||||||||||||||||
中文名称 | 达索曲林盐酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 31 mg/mL(94.32 mM) H2O : 1.61 mg/mL(4.90 mM;ultrasonic and warming and heat to 60℃) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |