CAS NO: | 76778-22-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | GBR 12935 is a potent, and selectivedopaminereuptake inhibitor, with the binding constant (Kd) of 1.08 nM in COS-7 cells. GBR 12935 stimulates the locomotion activity in different mice strains but fails to induce stereotypy. Thus, GBR 12935 also prevents the d-Fenfluramine-induced head-twitch response in mice[1][2][3][4]. | ||||||||
体外研究 (In Vitro) | GBR 12909 (10-100 nM) also shows a high affinity for CYP2D6 with the Kdvalue of 42.2 nM, lower than the affinity for dopamine transporter. The binding effect can be reduced byQuinidine(HY-B1751) andQuinine(HY-D0143), which are the specific and potent inhibitors of CYPZD enzymatic activities[1]. | ||||||||
体内研究 (In Vivo) | GBR 12935 (1-32 mg/kg; repeat injection; 7 d) elevates locomotion activity to a greater extent in C57BL/6J mice than DBA/2J mice, and (10 mg/kg; injection; 7 d) results few mice sensitized to cocaine-induced stereotypy with repeated injections[3].
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分子量 | 414.58 | ||||||||
Formula | C28H34N2O | ||||||||
CAS 号 | 76778-22-8 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |