| CAS NO: | 20724-73-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mM (in 1mL Water) | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 20724-73-6 |
| 别名 | 2'-C-甲基胞嘧啶核苷,2'-C-Methylcytidine; NM-107 |
| Canonical SMILES | NC(C=CN1[C@@H]2O[C@H](CO)[C@@H](O)[C@@]2(C)O)=NC1=O |
| 分子式 | C10H15N3O5 |
| 分子量 | 257.24 |
| 溶解度 | Water : ≥ 50 mg/mL (194.37 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NM107 is a inhibitors of HCV RNA replication with IC50 of 7.0 μM in vitro.IC50 value: 7.0 μMTarget:HCV RNA replicationNM107 is a potent and selective inhibitor of flavi- and pesti-virus replication in cell culture, with inhibitory activity and cytotoxicity against HCV 1b replicon cells, IC50 is 1.13 μM. Intracellular HCV RNA in HCV-infected cells treated the HCV polymerase inhibitor NM107 shows a similar pattern of decline. NM107 are currently being investigated as additional therapeutic agents for HCV infection. NM107 inhibits bovine viral diarrhea virus (BVDV) replication (EC50 0.67 nM), eliminates persistent BVDV infection at nontoxic concentrations. [1]. McCown MF, et al. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleosidepolymerase or protease inhibitors. Antimicrob Agents Chemother. 2008 May;52(5):1604-1612. |
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