| CAS NO: | 8001-54-5 |
| 包装: | 1g |
| 市场价: | 446元 |
| Cas No. | 8001-54-5 |
| 别名 | 苯扎氯铵; Alkyldimethylbenzylammonium chloride |
| Canonical SMILES | C[N+](C[(CH2)nCH3])(C)CC1=CC=CC=C1.[Cl-].[n=].[6 -16] |
| 分子式 | C6H5CH2N(CH3)2RCl (R=C8H17to C18H37) |
| 分子量 | 368.04 |
| 溶解度 | DMSO : 50 mg/mL ;Water : ≥ 20 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Benzalkonium chloride is a potent anti-microbial agent, used as a preservative in eye drops. Benzalkonium chloride (0.0001%-0.5%) results in a dose-dependent cytotoxicity in cells. Benzalkonium chloride also shows cytotoxicity against human keratinocytes, with 50% loss of viability of 4 μM. Benzalkonium chloride shows different results in NHEK and NB1RGB cell cultures, and the ED50 of 3.9 and 62 μM, respectively. The clinically used concentration (0.01% Benzalkonium chloride) significantly reduces cell viability, with only 14%-19% of nasal epithelial cells surviving the treatment[1]. Benzalkonium chloride (0.02%) causes no abnormalities in the nasal epithelium of the monkeys after light and electron microscopical examination. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1]. [1]. Johnson NF. Pulmonary Toxicity of Benzalkonium Chloride. J Aerosol Med Pulm Drug Deliv. 2017 Jul 6. |
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