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Opipramol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Opipramol图片
CAS NO:315-72-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
奥匹哌醇
Ensidon
G-33040
产品介绍
Opipramol (Ensidon) 是一种非典型的三环类抗抑郁试剂 (TCA)。Opipramol 主要用作 sigma (σ) 受体激动剂,可以有效地与 sigma 识别位点相互作用,Ki值为 50 nM。Opipramol 可用于广泛性焦虑症(GAD)的研究。
生物活性

Opipramol (Ensidon) is an atypical tricyclicantidepressant (TCA). Opipramol acts primarily as asigma (σ) receptoragonist and can potently interact with sigma recognition sites with aKivalue of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD)[1][2].

IC50& Target

Ki: 50 nM (σ receptor); IC50: 5.5 μM ([3H] DA)[1].

体外研究
(In Vitro)

Opipramol can potently interact with sigma recognition sites with a Kivalue of 50 nM[1].
Opipramol inhibit the uptake of [3H] DA in crude synaptosomal preparations with an IC50value of 5.5 μM[1].

体内研究
(In Vivo)

Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo[2].

Animal Model:Sprague-Dawley rats (male, 150-l 80 g)[2]
Dosage:5-50 mg/kg
Administration:Intraperitoneal injections
Result:Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA.
Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat.
Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.
Clinical Trial
分子量

363.50

Formula

C23H29N3O

CAS 号

315-72-0

中文名称

奥匹哌醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.