Todralazine (hydrochloride) (Ecarazine hydrochloride) 是一种抗高血压剂，作为 β2AR 阻滞剂，具有抗氧化和自由基清除活性。
| Cas No. | 3778-76-5 |
| 别名 | 盐酸托屈嗪,Ecarazine hydrochloride |
| 化学名 | 2-(1-phthalazinyl)-hydrazinecarboxylic acid, ethyl ester, monohydrochloride |
| Canonical SMILES | O=C(OCC)NNC1=C2C(C=CC=C2)=CN=N1.Cl |
| 分子式 | C11H12N4O2.HCl |
| 分子量 | 268.7 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 10 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): slightly |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Todralazine (hydrochloride) is a β2-adrenergic receptor antagonist with peripheral vasodilator activity. Administration of todralazine (5 uM) to pre-larval zebrafish led to hematopoietic cell expansion and protection from ionizing radiation. It inhibited histone acetylation in vitro and, long-term (4 months), but not short-term (1 month), treatment in mice (3 mg/day) impaired hepatocyte histone acetylation and liver regeneration. |
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