您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > (-)Clausenamide
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
(-)Clausenamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(-)Clausenamide图片
CAS NO:201529-58-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
(-)(Clausenamide) 是从黄皮 (Clausena lansium (Lour) skeels) 的树叶中分离出来的一种活性生物碱,在正常生理和病理条件下提高认知功能。(-)Clausenamide 抑制 β-淀粉样蛋白 () 毒性,通过抑制tau蛋白磷酸化阻止神经纤维缠结的形成。(-)Clausenamide 对 Aβ25-35的刺激具有显著的神经保护作用。(-)Clausenamide 可用于阿尔兹海默症的研究。
生物活性

(-)Clausenamide is an active alkaloid isolated from the leaves of Clausena lansium (Lour.) Skeels, and improves cognitive function in both normal physiological and pathological conditions. (-)Clausenamide inhibitsβ-amyloid(Aβ) toxicity, blocking neurofibrillary tangle formation by inhibiting the phosphorylation oftauprotein. (-)Clausenamide exerts a significant neuroprotective activity against Aβ25-35. (-)Clausenamide can be used for researching Alzheimer's disease (AD)[1][2][3].

体外研究
(In Vitro)

(-)Clausenamide (10 and 100 μM) reverses the overload in [Ca2+]ilevel stimulated by Aβ25-35, and reduces Aβ-mediated cell apoptosis in PC12 cells[3].
(-)Clausenamide (10 and 100 μM) inhibits the phosphorylation of p38 MAPK, down-regulates the expression of P53 and cleaved Caspase-3 and the ratio of Bax/Bcl-2, in Aβ25-35-treated PC12 cells[3].

分子量

297.35

Formula

C18H19NO3

CAS 号

201529-58-0

结构分类
  • Alkaloids
  • Other Alkaloids
来源
  • Plants
  • Rutaceae
  • Clausena lansium(Lour.) Skeels
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.