CAS NO: | 185351-19-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of thetau proteinwith generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46within the N-terminus of γD-crystallin) as well as full-length γD-crystallin[1]. | ||||||||||||||||
体外研究 (In Vitro) | In TEM analysis, GDC6 peptide fibrils (50 μM) in the presence of NQTrp 5:1, 1:1, 1:5 ratio (GDC6: NQTrp). NQTrp effectively inhibits the fibrillation of the GDC6 peptide (50 μM) in a dose-dependent manner and prevents the formation of elongated amyloid fibrils[1].NQTrp has no toxic effect toward retinal cell culture and reduces the cytotoxicity induced by aggregates of the hexapeptide(IC50=70 μM) in ARPE-19 cells[1]. | ||||||||||||||||
分子量 | 360.36 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H16N2O4 | ||||||||||||||||
CAS 号 | 185351-19-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 125 mg/mL(346.88 mM;ultrasonic and warming and heat to 60℃) 配制储备液
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