CAS NO: | 951395-08-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Tafamidis meglumine (Fx-1006A) is a potent and selectivetransthyretin (TTR)stabilizer, shows comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, withEC50s of 2.7-3.2 μM. Tafamidis meglumine inhibits amyloidogenesis[1]. | ||||||||||||||||
IC50& Target | EC50: 2.7-3.2 μM (TTR)[1] | ||||||||||||||||
体外研究 (In Vitro) | Tafamidis binds selectively and with negative cooperativity (Kds ~2 nM and ~200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 503.33 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H24Cl2N2O8 | ||||||||||||||||
CAS 号 | 951395-08-7 | ||||||||||||||||
中文名称 | 他发米帝司甲葡胺;氯苯唑酸甲葡胺盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 12.5 mg/mL(24.83 mM;Need ultrasonic) H2O :< 0.1 mg/mL(insoluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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