CAS NO: | 2739829-00-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Zidesamtinib (NVL-520) is a potent, selective, orally active and brain-penetrant inhibitor of diverseROS1 fusionsandresistance mutations, withIC50s of 0.7 and 7.9 nM forwild-type ROS1andROS1 G2032R, respectively, and sparesTRKinhibition. Zidesamtinib can be used for the research ofcancer[1]. | ||||||||
体外研究 (In Vitro) | Zidesamtinib (72 h) inhibits the growth of seven cell lines expressing wild-type ROS1 fusions, with average IC50s of 0.4 nM[1]. | ||||||||
体内研究 (In Vivo) | Zidesamtinib (0.04-15 mg/kg; p.o. twice daily for 28 d) induces tumor regression at all doses ≥0.2 mg/kg in wild-type ROS1 xenograft models[1].
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分子量 | 419.45 | ||||||||
Formula | C22H22FN7O | ||||||||
CAS 号 | 2739829-00-4 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |