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Isosorbide Dinitrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Isosorbide Dinitrate图片
CAS NO:87-33-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
硝酸异山梨酯 (ISDN) 是一种 NO 供体，可防止心肌梗死 (MI) 后 LV 重塑和心脏功能退化。
Cas No.87-33-2
别名硝酸异山梨酯; ISDN
Canonical SMILES[H][C@@]1([C@@H](O[N+]([O-])=O)CO2)[C@@]2([H])[C@H](O[N+]([O-])=O)CO1
分子式C6H8N2O8
分子量236.1
溶解度Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin.1 It induces vasodilation with IC50 values of 0.56 and 1.82 μM for isolated precontracted rabbit femoral vein and artery, respectively.2 Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model.3 It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range.4 Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris.

References
1. Ahlner, J., Andersson, R.G., Torfgard, K., et al. Organic nitrate esters: Clinical use and mechanisms of actions. Pharmacol. Rev. 43(3), 351-423 (1991).
2. Toyoda, J., Hisayama, T., and Takayanagi, I. Nitro compounds (isosorbide dinitrate, 5-isosorbide mononitrate and glyceryl trinitrate) on the femoral vein and femoral artery. Gen. Pharmacol. 17(1), 89-91 (1986).
3. Jordan, B.F., Misson, P., Demeure, R., et al. Changes in tumor oxygenation/perfusion induced by the no donor, isosorbide dinitrate, in comparison with carbogen: Monitoring by EPR and MRI. Int. J. Radiat. Oncol. Biol. Phys. 48(2), 565-570 (2000).
4. De Caterina, R., Giannessi, D., Bernini, W., et al. Organic nitrates: Direct antiplatelet effects and synergism with prostacyclin. Antiplatelet effects of organic nitrates. Thromb. Haemost. 59(2), 207-211 (1988).