CAS NO: | 1952251-28-3 |
包装 | 价格(元) |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | TAK-659 hydrochloride is a highly potent, selective, reversible and orally available dual inhibitor ofspleen tyrosine kinase (SYK)andfms related tyrosine kinase 3 (FLT3), with anIC50of 3.2 nM and 4.6 nM forSYKandFLT3, respectively. TAK-659 hydrochloride induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4]. | ||||||||||||||||
IC50& Target | IC50: 3.2 nM (Syk), 4.6 nM (FLT3)[1] | ||||||||||||||||
体外研究 (In Vitro) | TAK-659 hydrochloride inhibits cellular proliferation in SYK-dependent DLBCL and FLT3-dependent AML cell lines[1][3]. Apoptosis Analysis[4]
Western Blot Analysis[2]
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体内研究 (In Vivo) | TAK-659 hydrochloride (100 mg/kg/day; p.o.; daily, for 10 days) treatment totally abrogates splenomegaly and tumor development in LMP2A/MYC mice in both pretumor and tumor cell transfer experiments[4].
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Clinical Trial | |||||||||||||||||
分子量 | 380.85 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H22ClFN6O | ||||||||||||||||
CAS 号 | 1952251-28-3 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 2 mg/mL(5.25 mM;ultrasonic and adjust pH to 3 with HCl) DMSO :< 1 mg/mL(insoluble or slightly soluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |