CAS NO: | 726695-51-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Syk InhibitorII is a potent, high selective and ATP-competitiveSykinhibitor with anIC50of 41 nM.Syk InhibitorII inhibits5-HTrelease from RBL-cells with anIC50of 460 nM.Syk InhibitorII shows less potent against other kinases and has anti-allergic effect[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Syk Inhibitor II (compound 9a) shows less potent against PKCε, PKCβ2, ZAP-70, Btk, and Itk with IC50values of 5.1 μM, 11 μM, 11.2 μM, 15.5 μM, and 22.6 μM, respectively[1]. | ||||||||||||||||
体内研究 (In Vivo) | Syk Inhibitor II (Compound 9a; 10-100 mg/kg) is subcutaneously administered to mice 30 min before antigen challenge. Syk Inhibitor II inhibits the anaphylaxis reaction dose-dependently with an ID50value of 13.2 mg/kg[1]. | ||||||||||||||||
分子量 | 340.30 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C14H15F3N6O | ||||||||||||||||
CAS 号 | 726695-51-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 5 mg/mL(14.69 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |