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Tilvestamab
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:2226775-26-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
BGB149
产品介绍
Tilvestamab (BGB149) 是一种人源化抗AXL抗体,阻断AXL介导的细胞信号传导。Tilvestamab 在体外能显著抑制Gas6刺激诱导的AXL激活,并抑制 786-0-Luc RCC 细胞中下游AXL的磷酸化。Tilvestamab可用于癌症,尤其是AXL过度表达肾细胞癌的研究。
生物活性

Tilvestamab (BGB149) is a humanized anti-AXLantibody that blocksAXL-mediated cell signaling. Tilvestamab significantly inhibitsGas6-inducedAXLactivation in 786-0-Luc RCC cells and inhibits downstreamAKTphosphorylation. Tilvestamab can be used incancerresearch, particularly inAXLoverexpressing renal cell carcinomas[1].

IC50& Target

AXL[1].

体外研究
(In Vitro)

Tilvestamab (250 μM; 1 h) inhibits AXL phosphorylation in 786-0 cells[1].

Cell Viability Assay[1]

Cell Line:786-0-Luc cells (Gas6- induced; Gas6 is a well characterized AXL ligand)
Concentration:250 μM
Incubation Time:1 h (pre-treat)
Result:Drastically inhibited Gas6- induced AXL phosphorylation and decreased the level of pAKT.
体内研究
(In Vivo)

Tilvestamab (30 mg/kg; i.p.; twice a week) suppresses tumor growth by inhibiting AXL in orthotopic RCC model[1].

Animal Model:Female BALB/c athymic nude mice (8-week-old; orthotopic RCC model)[1].
Dosage:30 mg/kg
Administration:Intraperitoneal injection; twice a week
Result:Significantly inhibited RCC growth down to about 1/3 of the volume.
Clinical Trial
性状

Liquid

CAS 号

2226775-26-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.