CAS NO: | 2226775-26-2 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Tilvestamab (BGB149) is a humanized anti-AXLantibody that blocksAXL-mediated cell signaling. Tilvestamab significantly inhibitsGas6-inducedAXLactivation in 786-0-Luc RCC cells and inhibits downstreamAKTphosphorylation. Tilvestamab can be used incancerresearch, particularly inAXLoverexpressing renal cell carcinomas[1]. | ||||||||
IC50& Target | AXL[1]. | ||||||||
体外研究 (In Vitro) | Tilvestamab (250 μM; 1 h) inhibits AXL phosphorylation in 786-0 cells[1]. Cell Viability Assay[1]
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体内研究 (In Vivo) | Tilvestamab (30 mg/kg; i.p.; twice a week) suppresses tumor growth by inhibiting AXL in orthotopic RCC model[1].
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Clinical Trial | |||||||||
性状 | Liquid | ||||||||
CAS 号 | 2226775-26-2 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |