CAS NO: | 2229964-07-0 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | RGLS4326 (RG4326) is a first-in-class, short oligonucleotide inhibitor ofmicroRNA-17(miR-17). RGLS4326 can be used for the research of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 inhibits miR-17 function in HeLa cells with an EC50value of 28.3 nM[1]. | ||||||||
IC50& Target | MicroRNA[1] | ||||||||
体外研究 (In Vitro) | RGLS4326, a single-stranded, chemically modified, short oligonucleotide of 9-nt with full complementarity to the miR-17 seed sequence. RGLS4326 inhibits the pathologic functions of the miR-17 family of miRNAs in ADPKD[1]. Cell Proliferation Assay[1]
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体内研究 (In Vivo) | RGLS4326 preferentially distributes to kidney tubules and cysts. RGLS4326 (a single 30 mg/kg SC injection) is rapidly absorbed into plasma, showing Tmaxof ≤1 h, Cmaxof 8.5 μg/mL, and half-life of<4 h in wild-type mice[1].
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Clinical Trial | |||||||||
分子量 | 3082.42 | ||||||||
性状 | Solid | ||||||||
Formula | C95H115F3N32O51P8S8 | ||||||||
CAS 号 | 2229964-07-0 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | -20°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |