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CDK9-PROTAC
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CDK9-PROTAC图片
CAS NO:2118356-96-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
CDK9-PROTAC (PROTAC CDK9 Degrader-1) is a novel, potent and selective CDK9 (Cyclin-dependent kinase 9) degrader. CDK9-PROTAC is a heterobifunctional small molecule proteolysis targeting chimera (PROTAC) capable of cereblon (CRBN) mediated proteasomal degradation of CDK9. CDK9 is a member of the cyclin-dependent protein kinase (CDK) family that is involved in transcriptional elongation of several target genes. CDK9 is ubiquitously expressed and has been shown to contribute to a variety of malignancies such as pancreatic, prostate and breast cancers. In HCT116 cells, CDK9-PROTAC selectively degrades CDK9 while sparing other CDK family members. This is the first example of a PROTAC that selectively degrades CDK9.
理化性质和储存条件


Name: CDK9-PROTAC
CAS#: 2118356-96-8
Chemical Formula: C33H35N5O7
Exact Mass: 613.2536
Molecular Weight: 613.67
Elemental Analysis: C, 64.59; H, 5.75; N, 11.41; O, 18.25
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationSynonym: PROTAC CDK9 Degrader-1; PROTAC CDK9 Degrader1; PROTAC CDK9 Degrader 1; CDK9PROTAC; CDK9 PROTAC; CDK9-PROTAC
Chemical Name: N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-(4-((5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)pentyl)oxy)phenyl)acetamide
InChi Key: WCEHIDWONYOKOJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H35N5O7/c39-28-15-14-25(31(41)35-28)38-32(42)23-8-5-9-26(30(23)33(38)43)45-17-3-1-2-16-44-22-12-10-20(11-13-22)18-29(40)34-27-19-24(36-37-27)21-6-4-7-21/h5,8-13,19,21,25H,1-4,6-7,14-18H2,(H,35,39,41)(H2,34,36,37,40)
SMILES Code: O=C(NC1=NNC(C2CCC2)=C1)CC3=CC=C(OCCCCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)C=C3