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Uridine triphosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Uridine triphosphate图片
CAS NO:63-39-8
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
三磷酸尿苷
UTP
Uridine 5'-triphosphate
产品介绍
Uridine triphosphate (UTP;Uridine 5'-triphosphate) 是一种核苷酸,在正常和疾病状态时,调节胰腺内分泌和外分泌、增殖、通道、转运体和细胞内信号传导的功能。
生物活性

Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Uridine triphosphate treatment induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular matrix metalloproteinase-2 (MMP-2) activation and expression[1]. Uridine triphosphate-induced proliferation is mediated by protein kinase D, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, phosphatidylinositol 3-kinase (PI3K), Akt, and phospholipase D. Uridine triphosphate increases phosphorylation of Akt through protein kinase C, Src-family tyrosine kinase, Ca/calmodulin-dependent protein kinase II, and PI3K[2].

体内研究
(In Vivo)

Uridine triphosphate reduces mitochondrial calcium levels following hypoxia. Early or late uridine triphosphate preconditioning is effective to reduce infarct size and superior myocardial function[3]. Uridine triphosphate treatment increases the number of monocytes and macrophages infiltrating the pouch and up-regulates the gene expression of IL-4 and IL-13 in the regional lymph nodes[4].

Clinical Trial
分子量

484.14

性状

Solid

Formula

C9H15N2O15P3

CAS 号

63-39-8

中文名称

尿苷三磷酸;三磷酸尿苷;尿苷5'-三磷酸酯;尿苷-5'-三磷酸

结构分类
  • Ketones, Aldehydes, Acids
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : ≥ 150 mg/mL(309.83 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.0655 mL10.3276 mL20.6552 mL
5 mM0.4131 mL2.0655 mL4.1310 mL
10 mM0.2066 mL1.0328 mL2.0655 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 100 mg/mL (206.55 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。