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ATP dimagnesium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ATP dimagnesium图片
CAS NO:74804-12-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Adenosine 5'-triphosphate dimagnesium
产品介绍
ATP (Adenosine 5'-triphosphate) dimagnesium 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。ATP dimagnesium 是免疫和炎症中重要的内源性信号分子。
生物活性

ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation[1][2].

IC50& Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3].
ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4].
ATP promotes neutrophil chemotaxis in vitro[4].

体内研究
(In Vivo)

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4].
ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4].

Animal Model:Four-week-old Kunming mice (18-22 g)[4]
Dosage:50 mg/kg
Administration:Intraperitoneal injection, before bacterial (E. coli) challenge
Result:Protected mice from bacterial infection.
Clinical Trial
分子量

555.79

Formula

C10H16Mg2N5O13P3

CAS 号

74804-12-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.